解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::DNA methylation is a chromatin modification that contributes to epigenetic regulation of gene expression. The inheritance patterns and trans-generational stability of 962 differentially methylated regions (DMRs) were assessed in a panel of 71 near-isogenic lines (NILs) derived from maize (Zea mays) inbred lines B73 an...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.158980
更新日期:2014-03-01 00:00:00
abstract::Septin proteins bind GTP and heterooligomerize into filaments with conserved functions across a wide range of eukaryotes. Most septins hydrolyze GTP, altering the oligomerization interfaces; yet mutations designed to abolish nucleotide binding or hydrolysis by yeast septins perturb function only at high temperatures. ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.161182
更新日期:2014-03-01 00:00:00
abstract::Conifers are the predominant gymnosperm. The size and complexity of their genomes has presented formidable technical challenges for whole-genome shotgun sequencing and assembly. We employed novel strategies that allowed us to determine the loblolly pine (Pinus taeda) reference genome sequence, the largest genome assem...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.159715
更新日期:2014-03-01 00:00:00
abstract::We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), thereby taking advantage of rich haplotype information to infer local ancestry of admixed i...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.160697
更新日期:2014-03-01 00:00:00
abstract::We previously isolated a pollen factor, ui6.1, which encodes a Cullin1 protein (CUL1) that functions in unilateral interspecific incompatibility (UI) in Solanum. Here we show that CUL1 is also required for pollen function in self-incompatibility (SI). We used RNA interference (RNAi) to reduce CUL1 expression in pollen...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.158279
更新日期:2014-02-01 00:00:00
abstract::Gain or loss of chromosomes resulting in aneuploidy can be important factors in cancer and adaptive evolution. Although chromosome gain is a frequent event in eukaryotes, there is limited information on its genetic control. Here we measured the rates of chromosome gain in wild-type yeast and sister chromatid cohesion ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.159202
更新日期:2014-02-01 00:00:00
abstract::In fission yeast, the septation initiation network (SIN) is thought to promote cytokinesis by downstream activation of Rho1, a conserved GTPase that controls cell growth and division. Here we show that Etd1 and PP2A-Pab1, antagonistic regulators of SIN, are Rho1 regulators. Our genetic and biochemical studies indicate...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.155218
更新日期:2014-02-01 00:00:00
abstract::Development of the Caenorhabditis elegans foregut (pharynx) is regulated by a network of proteins that includes the Retinoblastoma protein (pRb) ortholog LIN-35; the ubiquitin pathway components UBC-18 and ARI-1; and PHA-1, a cytoplasmic protein. Loss of pha-1 activity impairs pharyngeal development and body morphogen...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.158485
更新日期:2014-01-01 00:00:00
abstract::Natural selection favors alleles that increase the number of offspring produced by their carriers. But in a world that is inherently uncertain within generations, selection also favors alleles that reduce the variance in the number of offspring produced. If previous studies have established this principle, they have l...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.156067
更新日期:2014-01-01 00:00:00
abstract::The RecQ helicase family is critical during DNA damage repair, and mutations in these proteins are associated with Bloom, Werner, or Rothmund-Thompson syndromes in humans, leading to cancer predisposition and/or premature aging. In the budding yeast Saccharomyces cerevisiae, mutations in the RecQ homolog, SGS1, phenoc...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.157370
更新日期:2013-12-01 00:00:00
abstract::Automated image acquisition, a custom analysis algorithm, and a distributed computing resource were used to add time as a third dimension to a quantitative trait locus (QTL) map for plant root gravitropism, a model growth response to an environmental cue. Digital images of Arabidopsis thaliana seedling roots from two ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.153346
更新日期:2013-11-01 00:00:00
abstract::The long terminal repeat retrotransposon, Magnaporthe gypsy-like element (MAGGY), has been shown to be targeted for cytosine methylation in a subset of Magnaporthe oryzae field isolates. Analysis of the F1 progeny from a genetic cross between methylation-proficient (Br48) and methylation-deficient (GFSI1-7-2) isolates...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.155978
更新日期:2013-11-01 00:00:00
abstract::Many insects feed on only one or a few types of host. These host specialists often evolve a preference for chemical cues emanating from their host and develop mechanisms for circumventing their host's defenses. Adaptations like these are central to evolutionary biology, yet our understanding of their genetics remains ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.154773
更新日期:2013-11-01 00:00:00
abstract::During meiosis, the stable pairing of the homologous chromosomes is mediated by the assembly of the synaptonemal complex (SC). Its tripartite structure is well conserved in Metazoa and consists of two lateral elements (LEs) and a central region (CR) that in turn is formed by several transverse filaments (TFs) and a ce...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.156679
更新日期:2013-11-01 00:00:00
abstract::The term "micro-evo-devo" refers to the combined study of the genetic and developmental bases of natural variation in populations and the evolutionary forces that have shaped this variation. It thus represents a synthesis of the fields of evolutionary developmental biology and population genetics. As has been pointed ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.113.156463
更新日期:2013-11-01 00:00:00
abstract::Knowledge of the rate and fitness effects of mutations is essential for understanding the process of evolution. Mutations are inherently difficult to study because they are rare and are frequently eliminated by natural selection. In the ciliate Tetrahymena thermophila, mutations can accumulate in the germline genome w...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.153536
更新日期:2013-10-01 00:00:00
abstract::Polycomb group response elements (PREs) play an essential role in gene regulation by the Polycomb group (PcG) repressor proteins in Drosophila. PREs are required for the recruitment and maintenance of repression by the PcG proteins. PREs are made up of binding sites for multiple DNA-binding proteins, but it is still u...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.153247
更新日期:2013-10-01 00:00:00
abstract::Constitutive transport of cellular materials is essential for cell survival. Although multiple small GTPase Rab proteins are required for the process, few regulators of Rabs are known. Here we report that EAT-17, a novel GTPase-activating protein (GAP), regulates RAB-6.2 function in grinder formation in Caenorhabditis...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.152538
更新日期:2013-09-01 00:00:00
abstract::Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase c...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.151019
更新日期:2013-09-01 00:00:00
abstract::Genetic adaptation to external stimuli occurs through the combined action of mutation and selection. A central problem in genetics is to identify loci responsive to specific selective constraints. Many tests have been proposed to identify the genomic signatures of natural selection by quantifying the skew in the site ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.152587
更新日期:2013-09-01 00:00:00
abstract::Cyclic guanosine monophosphate (cGMP) is a key secondary messenger used in signal transduction in various types of sensory neurons. The importance of cGMP in the ASE gustatory receptor neurons of the nematode Caenorhabditis elegans was deduced by the observation that multiple receptor-type guanylyl cyclases (rGCs), en...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.152660
更新日期:2013-08-01 00:00:00
abstract::Most studies of mutation rates implicitly assume that they remain constant throughout development of the germline. However, researchers recently used a novel statistical framework to reveal that mutation rates differ dramatically during sperm development in Drosophila melanogaster. Here a general framework is describe...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.151571
更新日期:2013-08-01 00:00:00
abstract::A canon of population genetics concerns the properties of FST, a descriptor of spatial genetic structure. Interest for FST arose from Wright's early insights linking FST to dispersal parameters as well as to his concept of effective population size (e.g., Wright 1938, 1951). Although there is continued interest in thi...
journal_title:Genetics
pub_type: 评论,杂志文章
doi:10.1534/genetics.113.152132
更新日期:2013-07-01 00:00:00
abstract::During the first weeks of human immunodeficiency virus-1 (HIV-1) infection, cytotoxic T-lymphocytes (CTLs) select for multiple escape mutations in the infecting HIV population. In recent years, methods that use escape mutation data to estimate rates of HIV escape have been developed, thereby providing a quantitative f...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.150862
更新日期:2013-07-01 00:00:00
abstract::The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient DNA polymerase γ mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, sug...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.150920
更新日期:2013-06-01 00:00:00
abstract::An article by Singh and colleagues in this issue of GENETICS quantifies variation in recombination rate across a small region of the Drosophila melanogaster genome, providing an opportunity for instructors of genetics to introduce or reinforce important concepts such as recombination and recombination rate variation, ...
journal_title:Genetics
pub_type: 评论,杂志文章
doi:10.1534/genetics.113.150771
更新日期:2013-06-01 00:00:00
abstract::Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, de...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.149104
更新日期:2013-05-01 00:00:00
abstract::An article from Alan Hinnebusch's laboratory in the March 2013 issue of GENETICS establishes an exciting new link between proteins with well-established roles in the endomembrane system and the process of transcription elongation. This Primer article provides tools needed for students to fully appreciate, analyze, and...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.113.150763
更新日期:2013-05-01 00:00:00
abstract::Long-range migrations and the resulting admixtures between populations have been important forces shaping human genetic diversity. Most existing methods for detecting and reconstructing historical admixture events are based on allele frequency divergences or patterns of ancestry segments in chromosomes of admixed indi...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.147330
更新日期:2013-04-01 00:00:00
abstract::There is increasing evidence that certain Vacuolar protein sorting (Vps) proteins, factors that mediate vesicular protein trafficking, have additional roles in regulating transcription factors at the endosome. We found that yeast mutants lacking the phosphatidylinositol 3-phosphate [PI(3)P] kinase Vps34 or its associa...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.146308
更新日期:2013-03-01 00:00:00
abstract::Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-function phenotypes, which cannot differentiate between separation-of-...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.147801
更新日期:2013-03-01 00:00:00
abstract::All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.112.147207
更新日期:2013-03-01 00:00:00
abstract::The genomic prediction of phenotypes and breeding values in animals and plants has developed rapidly into its own research field. Results of genomic prediction studies are often difficult to compare because data simulation varies, real or simulated data are not fully described, and not all relevant results are reporte...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.112.147983
更新日期:2013-02-01 00:00:00
abstract::Biofilms are microbial communities that form on surfaces. They are the primary form of microbial growth in nature and can have detrimental impacts on human health. Some strains of the budding yeast Saccharomyces cerevisiae form colony biofilms, and there is substantial variation in colony architecture between biofilm-...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.142067
更新日期:2013-02-01 00:00:00
abstract::Obligate pathogenic and endosymbiotic bacteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift. We hypothesize that reduced genomes increase their functional complexity through protein multitasking, in which many genes adopt new roles to counteract gene loss. Comparisons of i...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.145656
更新日期:2013-01-01 00:00:00
abstract::A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar "heavily ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.144329
更新日期:2013-01-01 00:00:00
abstract::To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant to globally ab...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.142042
更新日期:2013-01-01 00:00:00
abstract::Adaptive dynamics formalism demonstrates that, in a constant environment, a continuous trait may first converge to a singular point followed by spontaneous transition from a unimodal trait distribution into a bimodal one, which is called "evolutionary branching." Most previous analyses of evolutionary branching have b...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.144980
更新日期:2013-01-01 00:00:00
abstract::Animal microRNAs (miRNA) are implicated in the control of nearly all cellular functions. Due to high sequence redundancy within the miRNA gene pool, loss of most of these 21- to 24-bp long RNAs individually does not cause a phenotype. Thus, only very few miRNAs have been associated with clear functional roles. We cons...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.145383
更新日期:2012-12-01 00:00:00
abstract::Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of type II topoisomera...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.144006
更新日期:2012-11-01 00:00:00